| Autor: |
Corrado eGarbazza, Vivien eBromundt, Anne eEckert, Daniel P Brunner, Fides eMeier, Sandra eHackethal, Christian eCajochen |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neurology, Vol 7 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2295 |
| DOI: |
10.3389/fneur.2016.00017 |
| Popis: |
The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in an approximately 24h rhythm in accordance to the external light-dark (LD) cycle. While both individual processes are fairly well characterized, the exact nature of their interaction remains unclear. The circadian rhythm is generated by the subthalamic nucleus (SCN, master clock) of the anterior hypothalamus, through cell-autonomous feedback loops of DNA transcription and translation. While the phase length (tau) of the cycle is relatively stable and genetically determined, the phase of the clock is reset by external stimuli (zeitgebers), the most important being the LD-cycle. Misalignments of the internal rhythm with the LD-cycle can lead to various somatic complaints and ultimately to the development of circadian rhythm sleep disorders (CRSD). Non-24-h sleep-wake disorders (N24HSWD) is a CRSD affecting up to 50% of totally blind patients and characterized by the inability to maintain a stable entrainment of the typically long circadian rhythm (tau >24.5h) to the LD- cycle. The disease is rare ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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