GLP-1 RA for cardiometabolic risk reduction in obesity – How do we best describe benefit and value?

Autor: Sant Kumar, Michael J. Blaha
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100682- (2024)
Druh dokumentu: article
ISSN: 2666-6677
DOI: 10.1016/j.ajpc.2024.100682
Popis: How do we assess the overall benefit and value of GLP1-RAs? Current clinical trials often focus narrowly on individual atherosclerotic cardiovascular endpoints like MACE, potentially missing broader GLP-1 RA benefits across multiple comorbidities. Herein, we set out a framework for expanding outcome analyses in large trials that we believe will provide a more holistic understanding of GLP-1 RA benefits across the cardio-kidney-metabolic (CKM) spectrum, guiding patient care, guidelines, and insurance coverage decisions.
Databáze: Directory of Open Access Journals