Recent Development of Aminoacyl-tRNA Synthetase Inhibitors for Human Diseases: A Future Perspective

Autor:	Soong-Hyun Kim, Seri Bae, Minsoo Song
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	aminoacyl-tRNA synthetase small molecule inhibitors human diseases Microbiology QR1-502
Zdroj:	Biomolecules, Vol 10, Iss 12, p 1625 (2020)
Druh dokumentu:	article
ISSN:	10121625 2218-273X
DOI:	10.3390/biom10121625
Popis:	Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate amino acids to tRNAs and translate the genetic code during protein synthesis. Their function in pathogen-derived infectious diseases has been well established, which has led to the development of small molecule therapeutics. The applicability of ARS inhibitors for other human diseases, such as fibrosis, has recently been explored in the clinical setting. There are active studies to find small molecule therapeutics for cancers. Studies on central nervous system (CNS) disorders are burgeoning as well. In this regard, we present a concise analysis of the recent development of ARS inhibitors based on small molecules from the discovery research stage to clinical studies as well as a recent patent analysis from the medicinal chemistry point of view.
Databáze:	Directory of Open Access Journals
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