A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

Autor: Nimalini D. Moirangthem, Warjeet S. Laitonjam
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 1056-1060 (2010)
Druh dokumentu: article
ISSN: 1860-5397
DOI: 10.3762/bjoc.6.120
Popis: A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.
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