Dolutegravir-based regimens in treatment-naive and treatment-experienced aging populations: analyses of 6 phase III clinical trials

Autor:	Frank Spinelli, Manyu Prakash, Jill Slater, Mike van der Kolk, Niccolò Bassani, Richard Grove, Brian Wynne, Jean van Wyk, Andrew Clark
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	integrase strand transfer inhibitor virologic suppression antiretroviral therapy comorbidities polypharmacy older adults living with hiv Infectious and parasitic diseases RC109-216
Zdroj:	HIV Research & Clinical Practice, Vol 22, Iss 2, Pp 46-54 (2021)
Druh dokumentu:	article
ISSN:	2578-7470 25787489
DOI:	10.1080/25787489.2021.1941672
Popis:	Background: Older adults living with HIV (OALWH) are a growing population facing unique challenges to successful antiretroviral therapy. Objective: To assess efficacy and safety profiles of antiretroviral regimens, including those containing dolutegravir, in OALWH. Methods: Combined data from 6 phase III/IIIb trials in treatment-naive (ARIA, FLAMINGO, SINGLE, SPRING-2; N = 2634) and treatment-experienced (DAWNING, SAILING; N = 1339) participants receiving dolutegravir- or non–dolutegravir-based regimens were analyzed by age (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4176bce433b2463580ff6ef6d2dfbc94 Zobrazit plný text záznamu View record in DOAJ