| Autor: |
Yuanhao Yang, Yuan Zhou, Dale R. Nyholt, Chloe X. Yap, Rudolph K. Tannenberg, Ying Wang, Yang Wu, Zhihong Zhu, Bruce V. Taylor, Jacob Gratten |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Cell Genomics, Vol 3, Iss 2, Pp 100249- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-979X |
| DOI: |
10.1016/j.xgen.2022.100249 |
| Popis: |
Summary: Phenotypic associations have been reported between blood cell traits (BCTs) and a range of neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether these associations have a genetic basis and, if so, to what extent genetic correlations reflect causality. Here, we report genetic correlations and Mendelian randomization analyses between 11 NPDs and 29 BCTs, using genome-wide association study summary statistics. We found significant genetic correlations for four BCT-NPD pairs, all of which have prior evidence for a phenotypic correlation. We identified a previously unreported causal effect of increased platelet distribution width on susceptibility to Parkinson’s disease. We identified multiple functional genes and regulatory elements for specific BCT-NPD pairs, some of which are targets of known drugs. These results enrich our understanding of the shared genetic landscape underlying BCTs and NPDs and provide a robust foundation for future work to improve prognosis and treatment of common NPDs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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