| Autor: |
Christoph M. Mooshage, Lukas Schimpfle, Dimitrios Tsilingiris, Zoltan Kender, Taraneh Aziz-Safaie, Anja Hohmann, Julia Szendroedi, Peter Nawroth, Volker Sturm, Sabine Heiland, Martin Bendszus, Stefan Kopf, Johann M. E. Jende, Felix T. Kurz |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
European Radiology Experimental, Vol 8, Iss 1, Pp 1-11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2509-9280 |
| DOI: |
10.1186/s41747-023-00405-1 |
| Popis: |
Abstract Background Previous studies on magnetic resonance neurography (MRN) found different patterns of structural nerve damage in type 1 diabetes (T1D) and type 2 diabetes (T2D). Magnetization transfer ratio (MTR) is a quantitative technique to analyze the macromolecular tissue composition. We compared MTR values of the sciatic nerve in patients with T1D, T2D, and healthy controls (HC). Methods 3-T MRN of the right sciatic nerve at thigh level was performed in 14 HC, 10 patients with T1D (3 with diabetic neuropathy), and 28 patients with T2D (10 with diabetic neuropathy). Results were subsequently correlated with clinical and electrophysiological data. Results The sciatic nerve’s MTR was lower in patients with T2D (0.211 ± 0.07, mean ± standard deviation) compared to patients with T1D (T1D 0.285 ± 0.03; p = 0.015) and HC (0.269 ± 0.05; p = 0.039). In patients with T1D, sciatic MTR correlated positively with tibial nerve conduction velocity (NCV; r = 0.71; p = 0.021) and negatively with hemoglobin A1c (r = − 0.63; p |
| Databáze: |
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| Externí odkaz: |
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