| Autor: |
Decha Pinkaew, Abhijnan Chattopadhyay, Matthew D. King, Preedakorn Chunhacha, Zhihe Liu, Heather L. Stevenson, Yanjie Chen, Patuma Sinthujaroen, Owen M. McDougal, Ken Fujise |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-017-00029-1 |
| Popis: |
IRE1α is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1α, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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