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The effect of feeding rats with whey protein or lipoid microemulsion of n-3 rich linseed oil (LSO), and n-6 rich sunflower oil (SNO) compared to native or microemulsion forms of each oil for 60 days on fatty acid composition, Ca2+Mg2+ ATPase, Ca2+ uptake and membrane fluidity of rat cardiac sarcoplasmic reticulum (SR) were assessed. Rats consuming LSO in lipoid microemulsion showed higher levels of ALA (18:3, n-3) conversion to DHA (22:6, n-3) when compared to rats given LSO in native form. Compared to all other dietary treatments, the alterations in the n-6/n-3 PUFA composition of SR of rats given LSO in lipoid microemulsion effected the greatest changes in Ca2+Mg2+ ATPase activity and Ca2+ uptake which effectively reduced Ca2+ transport. Therefore, the LSO in lipoid microemulsion confers similar heart healthy fatty acid compositional and calcium transport changes and potentially anti-arrhythmic effects similar to fish oils. |
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