Association of potent inflammatory Cytokine and Oxidative DNA Damage Biomarkers in Stomach cancer patients
| Autor: | Akam Jasim Mustafa, Parween Abdulsamad Ismail |
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| Jazyk: | Arabic<br />English |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Baghdad Science Journal, Vol 19, Iss 6 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2078-8665 2411-7986 |
| DOI: | 10.21123/bsj.2022.6589 |
| Popis: | The infection with H. Pylori stimulates a signaling cascade that causes the generation of Cytokines and provokes Oxidative stress that is involved in the chronic inflammatory response leads to Gastric cancers. Reactive oxygen species (ROS) produce 8-Hydroxydeoxyguanosine (8-OHdG), the persistent oxidative DNA damage product. The study objective was to assess if there was a link between inflammatory cytokine levels and the presence of Oxidative DNA damage in Gastric tumor patients. In addition, evaluation of the diagnostic and prognostic value of Oxidative DNA damage and inflammatory cytokine biomarkers for Stomach cancers is being conducted. The study was accomplished on medically diagnosed Stomach cancer patients before any form of treatment. A total of 33 patients with Gastric cancers were selected and divided into Stages I, II, and III according to clinical pathology, and 32 age-matched healthy subjects as a control group. The Serum 8-OHdG, IL-6, TNF-α, IFN-γ & CEA were evaluated. The results revealed a highly significant rise (P |
| Databáze: | Directory of Open Access Journals |
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