The pattern of collagen production may contribute to the gluteal muscle contracture pathogenic process

Autor: Xiaocheng Jiang, Hang Zhang, Yuxiang Ren, Li Yang, Ling Zhong, Jiang Guo, Xintao Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 1749-799X
DOI: 10.1186/s13018-023-04069-w
Popis: Abstract Introduction Arthroscopic release is now the gold standard globally for gluteal muscle contracture (GMC) treatment. However, some patients fail to improve after the first operation and are forced to undergo a second operation. This study explores the essential role collagen fibers may play in muscle contracture in GMC. Methods From February 2010 to May 2018, 1041 hips of 543 GMC patients underwent arthroscopic release. Among them, 498 (91.7%) patients had bilateral GMC and were admitted to the retrospective cohort study. Pathological testing and type III collagen testing were used in contracture tissue studies. Single-cell RNA-sequencing analysis was applied to explore the role of fibroblasts in muscle repair. Results Compared with GMC II patients, GMC III patients displayed higher clinical symptoms (P
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