The role of SRP9/SRP14 in regulating Alu RNA
| Autor: | Daniel Gussakovsky, Nicole A. Black, Evan P. Booy, Sean A. McKenna |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | RNA Biology, Vol 21, Iss 1, Pp 1239-1250 (2024) |
| Druh dokumentu: | article |
| ISSN: | 15476286 1555-8584 1547-6286 |
| DOI: | 10.1080/15476286.2024.2430817 |
| Popis: | SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Alu RNA. Alu RNA are transcription products of Alu elements, a retroelement that comprises ~10% of the human genome. Alu RNA are involved in myriad biological processes and are dysregulated in several human disease states. This review focuses on the roles SRP9/SRP14 has in regulating Alu RNA diversification, maturation, and function. The diverse mechanisms through which SRP9/SRP14 regulates Alu RNA exemplify the breadth of protein-mediated regulation of non-coding RNA. |
| Databáze: | Directory of Open Access Journals |
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