| Autor: |
Caio Luiz Bitencourt Reis, Kelem Cristina Cambraia Caproni Guerra, Mariane Carolina Faria Barbosa, Fabricio Fernandes Ferreira, Daniela Coelho de Lima, Raquel Assed Bezerra Segato, Ana Cláudia Pedreira de Almeida, Mirian Aiko Nakane Matsumoto, Flares Baratto Filho, Maria Angélica Hueb de Menezes, Erika Calvano Küchler, Daniela Silva Barroso de Oliveira |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Oral Biology and Craniofacial Research, Vol 14, Iss 6, Pp 700-705 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2212-4268 |
| DOI: |
10.1016/j.jobcr.2024.09.012 |
| Popis: |
Introduction: Genetic polymorphisms who disturb the mineral homeostasis during tooth development and eruption are candidate to clarify the molecular mechanisms involved in changes in the tooth eruption chronology. In this study, we evaluate whether the FokI (rs2228570) and BglI (rs739837) polymorphisms in the Vitamin D receptor (VDR) gene are associated with changes in the chronology of eruption of permanent teeth. Material & method: This cross-sectional study randomly included 353 biologically unrelated children, both sexes, without systemic impairment or syndromes and history of trauma during the primary dentition. One operator perform the oral clinical examination. The tooth was considered erupted if there was a visible minimum of any tooth surface emerging from the mucosa. Genomic DNA was extracted from buccal epithelial cells from saliva samples. Genotyping was performed by Real-Time Polymerase Chain Reactions using TaqMan® technology. The average of the total number of erupted permanent teeth between the genotypes was compared by the Mann-Whitney test and multivariate Generalized Linear Models (GLM) (α = 5 %). β values with Confidence Interval (CI) 95 % were calculated. Results: The heterozygous adenine-guanine genotype of the FokI significantly decreases the number of erupted permanent teeth (β = −1.15; CI 95 % = −2.22 to −0.07; p = 0.036). In the stratified analysis for maxillary and mandibular teeth, this genotype was associated with a decrease in the number of erupted maxillary permanent teeth (β = −0.65; CI 95 % = −1.22 to −0.09; p = 0.023). BglI was not associated with permanent teeth eruption. Conclusion: The FokI, but not BglI, in the VDR may delay the eruption of permanent teeth. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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