Association of serum CTRP9 levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus

Autor: Junpeng Yang, Dongni Zhao, Yi Chen, Yuehua Ma, Xiaoyang Shi, Xiaobing Wang, Yinghua Lv, Huijuan Yuan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1442-1451 (2021)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13495
Popis: Abstract Aims Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes and is associated with adipokines. The C1q tumor necrosis factor‐related protein 9 (CTRP9) is a newly discovered adipokine. This study aimed to evaluate the association of serum CTRP9 levels with the prevalence and severity of CAN in patients with type 2 diabetes mellitus. Materials and Methods We enrolled 262 patients (aged ≥18 years) with type 2 diabetes mellitus into this study. Standard cardiovascular autonomic reflex tests (CARTs) were used to assess CAN and patients were divided into three groups accordingly: a non‐CAN group, an early CAN group, and a definite CAN group. Serum CTRP9 levels were measured by enzyme‐linked immunosorbent assay, and the tertiles were calculated. Results Serum CTRP9 levels decreased significantly in the early CAN and definite CAN groups (P
Databáze: Directory of Open Access Journals
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