Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B2pin2: Experimental and Computational Studies

Autor:	Lucilla Favero, Andrea Menichetti, Cosimo Boldrini, Lucrezia Margherita Comparini, Valeria Di Bussolo, Sebastiano Di Pietro, Mauro Pineschi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	copper catalysis diboron reagents aziridines aminoboronates DFT study Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 23, p 7399 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26237399
Popis:	The possibility to form new C–B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2pin2) in a regioselective nucleophilic addition reaction under copper catalysis.
Databáze:	Directory of Open Access Journals
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