Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non‐neoplastic erythrocytosis patients

Autor:	Yosuke Mori, Marito Araki, Soji Morishita, Misa Imai, Yoko Edahiro, Masafumi Ito, Tomonori Ochiai, Shuichi Shirane, Yoshinori Hashimoto, Hajime Yasuda, Jun Ando, Miki Ando, Norio Komatsu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	erythrocytosis myeloproliferative neoplasms erythropoietin drinking habit JAK2 lifestyle‐related disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 12, Iss 2, Pp 1079-1089 (2023)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.4958
Popis:	Abstract Background Acquired erythrocytosis can be classified into polycythemia vera (PV) and non‐neoplastic erythrocytosis (NNE). The vast majority of PV patients harbor JAK2 mutations, but differentiating JAK2 mutation‐negative PV from NNE is challenging due to a lack of definitive molecular markers. Methods We studied the clinical features of 121 patients with erythrocytosis of which 47 (38.8%) were JAK2 mutation‐positive and also fulfilled the diagnostic criteria for PV, and 67 (55.4%) JAK2 mutation‐negative erythrocytosis patients who were diagnosed as NNE. Diagnosis was strictly based on driver mutation analysis and central pathology review. Results No JAK2 mutation‐negative PV patients were found in our cohort. The NNE group showed significantly younger (p
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