Myocardial infarct border demarcation by dual-wavelength photoacoustic spectral analysis

Autor: Kangmu Ma, Shiying Wu, Shixing Huang, Weiya Xie, Mengjiao Zhang, Yingna Chen, Pengxiong Zhu, Jun Liu, Qian Cheng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Photoacoustics, Vol 26, Iss , Pp 100344- (2022)
Druh dokumentu: article
ISSN: 2213-5979
DOI: 10.1016/j.pacs.2022.100344
Popis: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Modern therapeutic strategies targeting the infarct border area have been shown to benefit overall cardiac function after MI. However, there is no non-invasive diagnostic technique to precisely demarcate the MI boundary till to now. In this study, the feasibility of demarcating the MI border using dual-wavelength photoacoustic spectral analysis (DWPASA) was investigated. To quantify specific molecular characteristics before and after MI, “the ratio of the areas of the power spectral densities (RAPSD)” was computed from the DWPASA results. Compared to the normal tissue, MI tissue was shown to contain more collagen, resulting in higher RAPSD values (p
Databáze: Directory of Open Access Journals