Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation

Autor: Jejoong Yoo, Hajin Kim, Aleksei Aksimentiev, Taekjip Ha
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms11045
Popis: Theoretical studies suggest that homologous DNA duplexes can preferentially associate with one another in the absence of proteins. Here, the authors show that GC-rich DNA with methylated cytosine and AT-rich DNA duplexes associate more strongly than GC-rich duplexes regardless of the sequence homology.
Databáze: Directory of Open Access Journals