SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

Autor: Caterina Ledda, Claudio Costantino, Giuseppe Motta, Rosario Cunsolo, Patrizia Stracquadanio, Giuseppe Liberti, Helena C. Maltezou, Venerando Rapisarda
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Tropical Medicine and Infectious Disease, Vol 7, Iss 1, p 9 (2022)
Druh dokumentu: article
ISSN: 2414-6366
DOI: 10.3390/tropicalmed7010009
Popis: The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: “Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*”. The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.
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