Appropriateness of antimicrobial use among septic patients managed by the critical care response team: an opportunity for improvement through de-escalation

Autor: Saad M. Al-Qahtani, Henry Baffoe-Bonnie, Aiman El-Saed, Majid Alshamrani, Abdullah Algwizani, Ali Alaklabi, Khuloud AlJoudi, Nahlah Albaalharith, Azzam Mohammed, Sajid Hussain, Hanan H. Balkhy
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 2047-2994
DOI: 10.1186/s13756-019-0609-0
Popis: Abstract Background Most septic patients managed by critical care response teams (CCRT) are prescribed antimicrobials. Nevertheless, data evaluating their appropriateness are lacking both locally and internationally. The objective was to assess antimicrobial use among septic and non-septic patients managed by CCRT. Setting Case-control design was used to compare septic (cases) and non-septic (controls) CCRT patients at tertiary care setting. The frequency of antimicrobial use was assessed before and after CCRT activation. The appropriateness of antimicrobial use was assessed at day four post-CCRT, based on standard recommendations, clinical assessment, and culture results. Main results A total of 157 cases and 158 controls were included. The average age was 61.1 ± 20.4 years, and 54.6% were males, with minor differences between groups. The use of any antimicrobial was 100.0% in cases and 87.3% in controls (p
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