Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis

Autor: Joaquín Bonelli, María Velasco-de Andrés, Neus Isidro, Cristina Bayó, Sergi Chumillas, Laura Carrillo-Serradell, Sergi Casadó-Llombart, Cheryl Mok, Daniel Benítez-Ribas, Francisco Lozano, Josep Rocas, Vicente Marchán
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pharmaceutics, Vol 15, Iss 1, p 58 (2022)
Druh dokumentu: article
ISSN: 15010058
1999-4923
DOI: 10.3390/pharmaceutics15010058
Popis: Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs’ surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer.
Databáze: Directory of Open Access Journals
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