An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence

Autor: Kevin Kalisz, Francesco Alessandrino, Rose Beck, Daniel Smith, Elias Kikano, Nikhil H. Ramaiya, Sree Harsha Tirumani
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Insights into Imaging, Vol 10, Iss 1, Pp 1-16 (2019)
Druh dokumentu: article
ISSN: 1869-4101
DOI: 10.1186/s13244-019-0733-7
Popis: Abstract Burkitt lymphoma (BL) is a highly aggressive, rapidly growing B cell non-Hodgkin lymphoma, which manifests in several subtypes including sporadic, endemic, and immunodeficiency-associated forms. Pathologically, BL is classically characterized by translocations of chromosomes 8 and 14 resulting in upregulation of the c-myc protein transcription factor with upregulation of cell proliferation. BL affects nearly every organ system, most commonly the abdomen and pelvis in the sporadic form. Imaging using a multimodality approach plays a crucial role in the management of BL from diagnosis, staging, and evaluation of treatment response to therapy-related complications with ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography playing roles. In this article, we review the pathobiology and classification of BL, illustrate a multimodality imaging approach in evaluating common and uncommon sites of involvement within the trunk and head and neck, and review common therapies and treatment-related complications.
Databáze: Directory of Open Access Journals
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