| Autor: |
Wei Hu, Yanhua Wang, Ting Wang, Qianpeng Ji, Qiang Jia, Tao Meng, Sai Ma, Zhihu Zhang, Yanbo Li, Rui Chen, Yufei Dai, Yang Luan, Zhiwei Sun, Shuguang Leng, Huawei Duan, Yuxin Zheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Environment International, Vol 147, Iss , Pp 106341- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0160-4120 |
| DOI: |
10.1016/j.envint.2020.106341 |
| Popis: |
Background: Oxidative stress has been suggested to be one of the key drivers of health impact of particulate matter (PM). More studies on the oxidative potential of PM alone, but fewer studies have comprehensively evaluated the effects of external and internal exposure to PM compositions on oxidative stress in population. Objective: To comprehensively investigate the exposure–response relationship between PM and its main compositions with oxidative stress indicators. Methods: We conducted a cross-sectional study including 768 participants exposed to particulates. Environmental levels of fine particulate matter (PM2.5), polycyclic aromatic hydrocarbons (PAHs) and metals in PM were measured, and urinary levels of PAHs metabolites and metals were measured as internal dose, respectively. Multivariable linear regression models were used to analyze the correlations of PM exposure and urinary levels of 8-hydroxy-2́′-deoxyguanosine (8-OHdG), and 8-iso-prostaglandin-F2α (8-iso-PGF2α) and malondialdehyde (MDA). Results: The concentration of both PM2.5 and total PAHs was significantly correlated with increased urinary 8-OHdG, 8-iso-PGF2α and MDA levels (all p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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