Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction
| Autor: | Damien Vitiello, François Harel, Rhian M. Touyz, Martin G. Sirois, Joel Lavoie, Jonathan Myers, Anique Ducharme, Normand Racine, Eileen O’Meara, Mathieu Gayda, Malorie Chabot-Blanchet, Jean Lucien Rouleau, Simon de Denus, Michel White |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | International Journal of Vascular Medicine, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-2824 2090-2832 |
| DOI: | 10.1155/2014/917271 |
| Popis: | Background. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL). Methods and Results. Eighteen HFpEF patients and 14 CTL were recruited. Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest. Brain natriuretic peptide (BNP) was measured at rest and peak exercise. Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses. Peripheral arterial blood flow was determined by strain gauge plethysmography. Peak VO2 (12.0±0.4 versus 19.1±1.1 mL/min/kg, P |
| Databáze: | Directory of Open Access Journals |
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