| Autor: |
Ruiling Xu, Junhui Sui, Mingda Zhao, Yuedi Yang, Lei Tong, Yongmei Liu, Yong Sun, Yujiang Fan, Jie Liang, Xingdong Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Polymer Testing, Vol 113, Iss , Pp 107669- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
0142-9418 |
| DOI: |
10.1016/j.polymertesting.2022.107669 |
| Popis: |
Human epidermal growth factor receptor-2 (HER-2) positive breast cancer is highly invasive with poor clinical outcomes and high risk of recurrence. Here, trastuzumab functionalized pullulan-doxorubicin nanoparticles (Tz-P-Dox) were developed and characterized as a new anticancer formulation for active targeting HER-2 overexpression of breast cancer cells. The obtained nanoparticles had the hydrodynamic diameter of 66.7 ± 2.0 nm and PDI of 0.218 ± 0.012. And the in vitro results showed significant difference of cell uptake and cytotoxic effect between Tz-P-Dox and non-targeted P-Dox against HER-2 positive cell lines (BT474 and MCF-7 cells). However, the differences between Tz-P-Dox and P-Dox were not observed in HER-2 negative cell lines (MDA-MB-231 cells). These results suggested that trastuzumab functionalized nanoparticles had great potential to be considered as a candidate drug for HER-2 positive breast cancer treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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