Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India
| Autor: | Kumar Jeyaprakash, Thennarasu Shanthini, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Indian Journal of Ophthalmology, Vol 69, Iss 8, Pp 2111-2115 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0301-4738 1998-3689 |
| DOI: | 10.4103/ijo.IJO_106_21 |
| Popis: | Purpose: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. Methods: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR. Results: Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome. Conclusion: Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB. |
| Databáze: | Directory of Open Access Journals |
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