| Autor: |
William P. Martin, MBChB, MSc, Lisa E. Vaughan, MS, Kotaro Yoshida, MD, PhD, Naoki Takahashi, MD, Marie E. Edwards, BSE, Andrew Metzger, MS, Sarah R. Senum, BS, Tetyana V. Masyuk, PhD, Nicholas F. LaRusso, MD, Matthew D. Griffin, MBChB, DMed, Ziad El-Zoghby, MD, Peter C. Harris, PhD, Walter K. Kremers, PhD, David M. Nagorney, MD, Patrick S. Kamath, MD, Vicente E. Torres, MD, PhD, Marie C. Hogan, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 3, Iss 2, Pp 149-159 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2542-4548 |
| DOI: |
10.1016/j.mayocpiqo.2019.03.004 |
| Popis: |
Objective: To describe first episodes of bacterial cholangitis complicating autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD) and to identify risk factors for cholangitis episodes among patients with ADPKD-associated polycystic liver disease (PLD). Patients and Methods: We searched the electronic medical records at our tertiary referral center for episodes of cholangitis in patients with ADPKD or ADPLD from January 1, 1996, through June 30, 2017. Cases were categorized as suspected or definite cholangitis by expert review. Clinical, laboratory, and radiologic data were manually abstracted. A nested case-control study was conducted to investigate risk factors for cholangitis in patients with ADPKD. Results: We identified 29 cases of definite or suspected cholangitis complicating PLD (24 with ADPKD-associated PLD and 5 with ADPLD). Among patients with definite cholangitis in ADPKD-associated PLD (n=19) vs ADPLD (n=4), the mean ± SD age was 62.4±12.2 vs 55.1±8.6 years, and 9 (47.4%) vs 0 (0%), respectively, were male. The odds of gallstones (odds ratio [OR], 21.6; 95% CI, 3.17-927; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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