Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine

Autor: DRAGANA M. MITIC, DJENANA U. MIODRAGOVIC, DUSAN M. SLADIC, ZELJKO J. VITNIK, ZORAN M. MIODRAGOVIC, KATARINA K. ANDJELKOVIC, MILANKA Dj. RADULOVIC, NENAD O. JURANIC
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Journal of the Serbian Chemical Society, Vol 73, Iss 8-9, Pp 815-824 (2008)
Druh dokumentu: article
ISSN: 0352-5139
Popis: In this study, the first complexes of Zn(II) with the N-benzyl-oxycarbonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans.
Databáze: Directory of Open Access Journals