Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2.

Autor: Heli Tiensuu, Antti M Haapalainen, Minna K Karjalainen, Anu Pasanen, Johanna M Huusko, Riitta Marttila, Marja Ojaniemi, Louis J Muglia, Mikko Hallman, Mika Rämet
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: PLoS Genetics, Vol 15, Iss 6, p e1008107 (2019)
Druh dokumentu: article
ISSN: 1553-7390
1553-7404
DOI: 10.1371/journal.pgen.1008107
Popis: Spontaneous preterm birth (SPTB) is the leading cause of neonatal death and morbidity worldwide. Both maternal and fetal genetic factors likely contribute to SPTB. We performed a genome-wide association study (GWAS) on a population of Finnish origin that included 247 infants with SPTB (gestational age [GA] < 36 weeks) and 419 term controls (GA 38-41 weeks). The strongest signal came within the gene encoding slit guidance ligand 2 (SLIT2; rs116461311, minor allele frequency 0.05, p = 1.6×10-6). Pathway analysis revealed the top-ranking pathway was axon guidance, which includes SLIT2. In 172 very preterm-born infants (GA
Databáze: Directory of Open Access Journals
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