Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes

Autor: Hana Polasek-Sedlackova, Thomas C. R. Miller, Jana Krejci, Maj-Britt Rask, Jiri Lukas
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33887-5
Popis: For several decades the MCM2-7 proteins, the core of the DNA replicative helicase, eluded detection at DNA replication sites. Here, the authors solve this conundrum by gene editing, which enables visualization of replication dynamics in living cells.
Databáze: Directory of Open Access Journals