An Evaluation of the Lineage of Brucella Isolates in Turkey by a Whole-Genome Single-Nucleotide Polymorphism Analysis

Autor: Kadir Akar, Katharina Holzer, Ludwig E. Hoelzle, Gülseren Yıldız Öz, Shaimaa Abdelmegid, Emin Ayhan Baklan, Buket Eroğlu, Eray Atıl, Shawky A. Moustafa, Gamal Wareth, Manar Elkhayat
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Veterinary Sciences, Vol 11, Iss 7, p 316 (2024)
Druh dokumentu: article
ISSN: 2306-7381
DOI: 10.3390/vetsci11070316
Popis: Brucellosis is a disease caused by the Brucella (B.) species. It is a zoonotic disease that affects farm animals and causes economic losses in many countries worldwide. Brucella has the ability to persist in the environment and infect the host at low doses. Thus, it is more important to trace brucellosis outbreaks, identify their sources of infection, and interrupt their transmission. Some countries already have initial data, but most of these data are based on a Multiple-Locus Variable-Number Tandem-Repeat Analysis (MLVA), which is completely unsuitable for studying the Brucella genome. Since brucellosis is an endemic disease in Turkey, this study aimed to examine the genome of Turkish Brucella isolates collected between 2018 and 2020, except for one isolate, which was from 2012. A total of 28 strains of B. melitensis (n = 15) and B. abortus (n = 13) were analyzed using a core-genome single-nucleotide polymorphism (cgSNP) analysis. A potential connection between the Turkish isolates and entries from Sweden, Israel, Syria, Austria, and India for B. melitensis was detected. For B. abortus, there may be potential associations with entries from China. This explains the tight ties found between Brucella strains from neighboring countries and isolates from Turkey. Therefore, it is recommended that strict measures be taken and the possible effects of uncontrolled animal introduction are emphasized.
Databáze: Directory of Open Access Journals