Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study
| Autor: | Changyang Xing, Xiujing Xie, Yu Wu, Lei Xu, Xiangping Guan, Fan Li, Xiaojun Zhan, Hengli Yang, Jinsong Li, Qi Zhou, Yuming Mu, Qing Zhou, Yunchuan Ding, Yingli Wang, Xiangzhu Wang, Yu Zheng, Xiaofeng Sun, Hua Li, Chaoxue Zhang, Cheng Zhao, Shaodong Qiu, Guozhen Yan, Hong Yang, Yinjuan Mao, Weiwei Zhan, Chunyan Ma, Ying Gu, Wu Chen, Mingxing Xie, Tianan Jiang, Lijun Yuan, Jinjiao Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Chinese Medical Journal, Vol 137, Iss 15, Pp 1802-1810 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0366-6999 2542-5641 00000000 91512441 |
| DOI: | 10.1097/CM9.0000000000003156 |
| Popis: | Abstract. Background:. Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical determinants. Methods:. A total of 3053 healthy Han Chinese adults (1922 women) aged 18–79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere–Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of covariance. Results:. All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (all P for age by sex interaction |
| Databáze: | Directory of Open Access Journals |
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