Autor: |
Viviana Volta, Sandra Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
|
Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-021-27087-w |
Popis: |
The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving translation factors DAP5 and eIF3d. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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