Analysis of Neutralization Antibodies in Patients With Mild COVID-19 Infection After 100 Days Using Microneutralization Test
| Autor: | Min-Ju Ahn, Dae Gwin Jeong, Kyu-Sun Lee, Seungjun Lee, Byung-Han Ryu, Hye Ryun Yang, Sunjoo Kim |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of Clinical Microbiology, Vol 25, Iss 1, Pp 29-33 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2288-0585 2288-6850 |
| DOI: | 10.5145/ACM.2022.25.1.4 |
| Popis: | Neutralizing antibodies play a critical role in blocking viral infections and in viral clearance during acute infection. The microneutralization assay and enzyme-linked immunosorbent assay (ELISA) targeting the receptor binding domain were performed for 30 patients with mild coronavirus disease (COVID)-19 infections. The elapsed number of days between sample collection and diagnosis was 115 days, and real-time polymerase chain reaction (PCR) cycle threshold (Ct) values at diagnosis were recorded. Clinical characteristics and Ct values were compared between neutralization antibody-positive and -negative patients as measured by the microneutralization assay. Neutralization antibody-positive patients (n = 9) were likely to be older, have low Ct values, have more pneumonia during admission, and have a higher optical density in ELISA than the neutralization antibody-negative patients (n = 21). Elderly people seemed to have a higher viral load causing more pneumonia and to produce more neutralization antibodies. Neutralization antibodies persisted in only 30% of patients as detected by microneutralization test after 100 days of diagnosis. |
| Databáze: | Directory of Open Access Journals |
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