Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study

Autor: Gilles Darcis, Antoine Bouquegneau, Nathalie Maes, Marie Thys, Monique Henket, Florence Labye, Anne-Françoise Rousseau, Perrine Canivet, Colin Desir, Doriane Calmes, Raphael Schils, Sophie De Worm, Philippe Léonard, Paul Meunier, Michel Moutschen, Renaud Louis, Julien Guiot
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 109, Iss , Pp 209-216 (2021)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2021.07.016
Popis: ABSTRACT: Objectives: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. Methods: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. Results: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P
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