| Autor: |
Francisco Rodríguez-Esparragón, Laura B. Torres-Mata, Juan Carlos López-Fernández, Laura Cappiello, Jesús M. González-Martín, Bernardino Clavo, Jaime A. Serna-Gómez, Lidia Estupiñán-Quintana, Cristina Torres-Ascensión, Jesús Villar |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2261 |
| DOI: |
10.1186/s12872-021-02421-8 |
| Popis: |
Abstract Background Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) patients and predictors of their variance evaluated. Methods This is a single-center observational study evaluating 187 consecutively hospitalized patients with IS. EPCs were isolated from blood samples. The number of circulating angiogenic cells (CACs), colony-forming units (CFU-ECs) and the emergence of late outgrowths endothelial cells (LOECs) were counted. We collected clinical variables and measured the stromal cell-derived factor 1 alpha (SDF1α) serum levels. We also examined the relative telomere length and the expression of osteogenic gene markers in CACs. Results CACs counts and CFU-ECs colony numbers were positively correlated (rho = 0.41, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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