miR-145a-5p/Plexin-A2 promotes the migration of OECs and transplantation of miR-145a-5p engineered OECs enhances the functional recovery in rats with SCI

Autor:	MinChao Zhao, Jiaxi Li, Zhengchao Gao, Dong Guo, Yubing Yang, Fang Wang, Lumin Wang, Yang Yang, Xijing He, Haopeng Li, Su’e Chang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	miR-145a-5p Plexin-A2 OECs Migration Nerve repair Spinal cord injury Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Neurobiology of Disease, Vol 182, Iss , Pp 106129- (2023)
Druh dokumentu:	article
ISSN:	1095-953X
DOI:	10.1016/j.nbd.2023.106129
Popis:	Background: Olfactory ensheathing cells (OECs) serve as a bridge by migrating at the site of spinal cord injury (SCI) to facilitate the repair of the neural structure and neural function. However, OEC migration at the injury site not only faces the complex and disordered internal environment but also is closely associated with the migration ability of OECs. Methods: We extracted OECs from the olfactory bulb of SD rats aged
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/401f602aa2a743ba8584e5090e8ccc5b Zobrazit plný text záznamu Full Text from ScienceDirect View record in DOAJ