Clinical characteristics of new‐onset diabetes after liver transplantation and outcomes

Autor: Shingo Shimada, Katsunori Miyake, Deepak Venkat, Humberto Gonzalez, Dilip Moonka, Atsushi Yoshida, Marwan Abouljoud, Shunji Nagai
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Gastroenterological Surgery, Vol 8, Iss 3, Pp 383-393 (2024)
Druh dokumentu: article
ISSN: 2475-0328
DOI: 10.1002/ags3.12775
Popis: Abstract Background We aimed to identify the characteristics of new‐onset diabetes after liver transplantation (LT) (NODAT) and investigate its impacts on post‐transplant outcomes. Methods Adult LT patients between 2014 and 2020 who used tacrolimus as initial immunosuppression and survived 3 months at least were evaluated. Patients who developed NODAT within 3 months after LT were classified as NODAT group. Also, patients were further classified as history of diabetes before LT (PHDBT) and non‐diabetes (ND) groups. Patient characteristics, post‐LT outcomes, and cardiovascular and/or pulmonary complications were compared. Results A total of 83, 225, and 263 patients were classified into NODAT, PHDBT, and ND groups. The proportion of cholestatic liver disease and rejection within 90 days were higher in NODAT group. Mean serum tacrolimus concentration trough level in the first week after LT was 7.12, 6.12, and 6.12 ng/mL (p
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