Rapid development of HPV-mediated oropharyngeal squamous cell carcinoma in the setting of immune suppression following autologous stem cell transplantation for Hodgkin lymphoma

Autor: Joo Y. Song, Ellie Maghami, Huiqing Wu, Young S. Kim, Dennis D. Weisenburger, Alexandra Levine, Auayporn Nademanee
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Human Pathology: Case Reports, Vol 9, Iss , Pp 43-45 (2017)
Druh dokumentu: article
ISSN: 2214-3300
DOI: 10.1016/j.ehpc.2016.10.001
Popis: The patient is a 61-year-old male with a diagnosis of relapse classical Hodgkin lymphoma, treated with ABVD, ICE, and achieved remission. He underwent autologous stem cell transplantation and 3 months later found to have a PET-positive neck node concerning for relapsed disease of Hodgkin lymphoma. Biopsy proved the lesion was HPV-associated squamous cell carcinoma and not relapse Hodgkin disease. Iatrogenic immunosuppression such as bone marrow transplantation can cause substantial increase risk for viral-associated tumors and therefore tissue biopsies are necessary to make that distinction to avoid inappropriate treatment. Keywords: Hodgkin lymphoma, HPV, Squamous cell carcinoma, Transplantation
Databáze: Directory of Open Access Journals