| Autor: |
Yunan Zhao, Yongwei Gu, Fu Qi, Aixue Li, Xiaomeng Tang, Dan Li, Xin Wu, Jiyong Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Materials & Design, Vol 228, Iss , Pp 111860- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0264-1275 |
| DOI: |
10.1016/j.matdes.2023.111860 |
| Popis: |
Malignant melanoma (MM) is an aggressive and easily metastatic cancer that is poorly responsive to current therapy. The crosstalk between melanoma cells and tumor-associated adipocytes (TAA) plays an important role in the progression of MM, which could be leveraged for anticancer treatment. Here, mature adipocytes (Apo) were engineered for encapsulating a palmitic acid-conjugated triptolide derivative (pTP) and photosensitizer Ce6 (named as pTP-Ce6-Apo), to induce a cytotoxic and photodynamic treatment in malignant melanoma. After para-tumor administration, lipolysis releases pTP and Ce6 that is triggered by intracellular glutathione (GSH) and laser irradiation, respectively, subsequently inducing a variety of pathways, inducing the caspase apoptosis program; generation of reactive oxygen species (ROS), and endoplasmic reticulum (ER) stress. Overall, pTP-Ce6-Apo exhibited excellent antitumor performance and high safety, which is desired for MM therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect