Differences in Efficacy between Antibacterial Lock Therapy and the Standard of Care for CVC-Related Infections: A Systematic Review and Meta-Analysis

Autor: Vincenzo Calabrese, Alessandra Farina, Veronica Maressa, Valeria Cernaro, Guido Gembillo, Roberta Maria Messina, Elisa Longhitano, Cinzia Ferio, Emanuele Venanzi Rullo, Domenico Santoro
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinics and Practice, Vol 14, Iss 4, Pp 1538-1549 (2024)
Druh dokumentu: article
ISSN: 2039-7283
DOI: 10.3390/clinpract14040124
Popis: Background: Central Venous Catheter (CVC)-related infections cannot always be solved by replacement, due to some vascular anomalies or an emergency status. This comprehensive, evidence-based review aimed to define the efficacy of antibacterial lock therapy (ALT) compared to the standard of care (SoC) in CVC-related infections. Methods: We performed a systematic search in PubMed, Embase, and Google Scholar, looking for randomized controlled trials (RCTs) and cohort or case-control observational studies. The eligible studies considered the subjects with a diagnosis of CVC-related infections treated with antibacterial lock therapy (ALT) compared to the standard of care (SoC). Results: Among 609 records at the end of the selection process, five articles, referring to observational studies, were included in this systematic review. In pooled analyses, including a total of 276 individuals, microbiological healing (OR 3.78; 95% CI; 2.03–7.03) showed significant differences between ALT and the SoC, with a follow-up varying from 2 weeks to 3 months. Conclusions: Our results suggested that ALT could improve the preservation of CVCs and could be considered when their replacement is not possible as a result of vascular problems. However, only observational studies were included and RCTs are needed to confirm these findings and to increase the level of evidence.
Databáze: Directory of Open Access Journals
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