| Autor: |
Shuichi Hara, Toshiji Mukai, Hajime Mizukami, Fumi Kuriiwa, Takashi Watanabe, Takahiko Endo |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 104, Iss 1, Pp 90-93 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.SC0070062 |
| Popis: |
Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O2 was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O2, was transiently increased. A nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine, strongly reduced the steady-state level of extracellular cGMP in the striatum, indicating a primary role of NO in cGMP production. However, it failed to suppress the CO-induced increase in extracellular cGMP in the striatum. These findings suggest that CO may stimulate cGMP production in rat striatum independently of NO and hypoxia. Keywords:: carbon monoxide, cGMP, rat striatum |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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