The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants

Autor: Gaston Ofman, Mauricio T. Caballero, Damian Alvarez Paggi, Jacqui Marzec, Florencia Nowogrodzki, Hye-Youn Cho, Mariana Sorgetti, Guillermo Colantonio, Alejandra Bianchi, Luis M. Prudent, Nestor Vain, Gonzalo Mariani, Jorge Digregorio, Elba Lopez Turconi, Cristina Osio, Fernanda Galletti, Mariangeles Quiros, Andrea Brum, Santiago Lopez Garcia, Silvia Garcia, Douglas Bell, Marcus H. Jones, Trent E. Tipple, Steven R. Kleeberger, Fernando P. Polack
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Pediatrics, Vol 19, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 1471-2431
DOI: 10.1186/s12887-019-1610-8
Popis: Abstract Background Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210–213, 2017; Isayama et la., JAMA Pediatr 171:271–279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease. Methods The Discovery BPD (D-BPD) Program involves a cohort of infants
Databáze: Directory of Open Access Journals
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