Association between ACTN3 gene polymorphism and muscle strength in older adults

Autor: Sylwester Kłoska, Anna Marciniak, Marcin Woźniak, Radosław Perkowski, Marta Podhorecka, Dominika Gębka, Joanna Androsiuk-Perkowska, Sławomir Kujawski, Marcin Kożuchowski, Henryk Kozłowski, Kornelia Kędziora-Kornatowska, Walery Zukow
Jazyk: English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian
Rok vydání: 2018
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 8, Iss 9, Pp 155-165 (2018)
Druh dokumentu: article
ISSN: 2391-8306
DOI: 10.5281/zenodo.1345234
Popis: The decrease of muscle strength and general physical fitness is a big problem in the elderly group. It often prevents the proper functioning of a person, which makes him/her dependent on caretakers. It is believed that the some polymorphisms in ACTN3 geneare associated with better results in strength sports. If those polymorphisms affect muscle strength, they may also be related to the health condition of older people. Our study was conducted on a group of 60 people over 60 years of age. The relationship between overall fitness and muscular strength of elderly patients with ACTN R577X gene polymorphism was checked. The ACTN3 gene was tested by PCR-RFLP. Overall fitness was tested using the IPAQ questionnaire and fitness tests: Tinetti, DGI, Up&Go, SPPB, standing on one leg (both right and left). Based on the results of the survey, the MET and BMI coefficients were determined. It was found that the RX genotype is associated with better results achieved in the SPPB test. Genotype XX was associated with worse results in the right leg standing test (p
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