Occurrence of Psoriatic Arthritis during Interferon Beta 1a Treatment for Multiple Sclerosis
| Autor: | Éric Toussirot, Matthieu Béreau, Marie Bossert, Imad Malkoun, Anne Lohse |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Case Reports in Rheumatology, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-6889 2090-6897 |
| DOI: | 10.1155/2014/949317 |
| Popis: | Interferon beta (IFN-β) is the first line therapy of relapsing-remitting multiple sclerosis. IFN-β is a cytokine that can contribute to the development of systemic autoimmune disease including psoriasis. The development or the exacerbation of psoriasis during IFN-β treatment has been previously observed. We report the occurrence of arthritis and dactylitis in a multiple sclerosis patient with preexisting psoriasis diagnosed as a psoriatic arthritis. The IL-23/Th17 pathway is involved in psoriasis and psoriatic arthritis and it has been suggested that IFN-β therapy in patients with Th17-mediated disease may be detrimental. Together with previous similar reports, our case suggests that IFN-β should certainly be used with caution in patients with concomitant systemic autoimmune disease with IL-23/Th17 involvement. |
| Databáze: | Directory of Open Access Journals |
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