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Ju Qiu,1 Zaigui Li,2 Yuchang Qin,1 Yanfen Yue,3 Yanping Liu4 1Institute of Food and Nutrition Development, Ministry of Agriculture, 2College of Food Science and Nutritional Engineering, China Agricultural University, 3Department of Nutrition, Pinggu Hospital of Traditional Chinese Medicine, Pinggu, 4Department of Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Abstract: Tartary buckwheat (TB) has been reported to be associated with a decreased risk of type 2 diabetes mellitus (T2DM), and T2DM has had a major impact on the development of diabetic kidney disease (DKD). Thus, the hypothesis that a daily intake of TB will improve DKD risk factors, including urinary albumin to creatinine ratio (UACR), urea nitrogen (UN), serum creatinine, and uric acid was tested. In a parallel, randomized, open-label controlled trial, 104 T2DM patients were randomly assigned to a diet control group (systematic diet plans and intensive nutritional education) or a TB intervention group (daily replacement of a portion of staple foods with TB foods). Blood samples and dietary information were collected at baseline and the end of the 4-week study. The primary outcomes were that TB significantly decreased the relative changes in UACR (2.43–2.35, logarithmic transformed mg/g creatinine) and UN (5.12–4.91 mmol/L) in the TB intervention group vs the diet control group at 4 weeks (P |
