Elevation of D-dimer levels are associated with early need for mechanical ventilation support in patients with COVID-19

Autor: Asmaa Ali, Wu Liang, Ahmed Samir Abdelhafiz, Mai M. Saleh, Heba Salem, Eman M. Moazen, Maram I. Elmazny, Mohammed Abdallah Rakha, Seham Ezzat Fathy Elfeky
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-8 (2023)
Druh dokumentu: article
ISSN: 1471-2466
DOI: 10.1186/s12890-023-02551-z
Popis: Abstract Background Severe COVID-19 disease is typically associated with an urgent need for supplemental oxygen therapy that may be successfully delivered through conventional methods or require invasive mechanical ventilation. Early prediction of the need for invasive mechanical ventilation could significantly improve outcomes of COVID-19 patients. Plasma levels of D-dimer and a number of inflammatory markers as well as values of complete blood counts, all measured in the first two days of hospital admission of COVID-19 patients, were evaluated for their significance as predictors of the eventual need for invasive mechanical ventilation support as well as their values as predictors of post-ventilation morbidly and mortality. Methods This retrospective cohort study was conducted at a single center and included data pertaining to 200 patients with previously confirmed moderate to severe COVID-19 disease in the period between May 2021 and the end of December 2022. Data were retrieved from medical records for further analysis. Results The mean (SD) age of patients stood at 59 (14) years of age, and with a majority of patients being male (77%). About 18% of cases, all of significantly older age, had been connected to invasive mechanical ventilation (IMV). Total leucocytic count (TLC), as well as levels of urea, creatinine, D-dimer, ferritin, and CRP in IMV patients were significantly higher than non-ventilated patients (p
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