Histopathological spectrum of ocular surface squamous neoplasia: A retrospective study of 776 lesions

Autor: Dilip Kumar Mishra, Shikha Taneja, Vivek Singh, Uppala Veena, Swathi Kaliki
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Indian Journal of Pathology and Microbiology, Vol 65, Iss 1, Pp 3-7 (2022)
Druh dokumentu: article
ISSN: 0377-4929
DOI: 10.4103/IJPM.IJPM_1313_20
Popis: Background: Ocular surface squamous neoplasia (OSSN) comprises neoplasm arising from the ocular surface, which includes conjunctiva, cornea, and limbus and ranges from mild dysplasia to invasive squamous cell carcinoma. Purpose: The aim of this work was to study the spectrum of OSSN based on histopathological analysis. Materials and Methods: This was a retrospective cross-sectional study comprising 776 histopathologically diagnosed cases of OSSN from January 2004 to December 2014. Results: The mean age of presentation of OSSN was 45 years (median, 45 years; 2 to 87 years) with male preponderance (74%). The most common age group of presentation was 41–60 years (n = 299; 39%). The most common type of OSSN was invasive squamous cell carcinoma seen in 50% (n = 383) eyes followed by severe dysplasia/carcinoma in situ in 31% (n = 250) eyes. Tumor infiltration at base was seen in 16% (n = 124), positive margins in 32% (n = 248), scleral infiltration in 14% (n = 109), intraocular extension in 3% (n = 23), and orbital extension in 4% (n = 26) eyes. OSSN was associated with actinic keratosis in 21% (n = 165) cases. Conclusion: Based on histopathology, invasive squamous cell carcinoma is the most common form of OSSN in the Asian Indian population.
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