Diastereoselective Synthesis of 5-Hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one

Autor: Thomas W. Scully, Guy L. Plourde
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Molecules, Vol 18, Iss 1, Pp 1174-1180 (2013)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules18011174
Popis: A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV) acetate.
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