| Autor: |
R.S. Rosenfeld, Barnett Zumoff, Leon Hellman |
| Jazyk: |
angličtina |
| Rok vydání: |
1963 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 4, Iss 3, Pp 337-340 (1963) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)40311-6 |
| Popis: |
Coprostanol-C14, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C14 was administered to one of them 10 months later. At the time when radioactivity in the circulation was at a maximum, 3.6 and 3.5% of the administered labeled coprostanol was present in the plasma; the corresponding value after administration of cholestanol-C14 was 4.7%. The dynamic behavior of absorbed radioactive cholestanol was identical with that of orally ingested cholesterol-4-C14, including the esterification process; on the other hand, virtually no coprostanol ester was present in the circulation. It is suggested that the conformation of the A/B rings or configuration at C-3 are related to the esterification mechanism of sterols. After 5 days, over 50% of both compounds had been excreted in the feces. The conversion of coprostanol-C14 to coprostanone-C14 has been demonstrated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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